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Sunday, November 18, 2007

In the quarter-final of 2007 Baseball World Cup, because actual strengths of those finalists were merely close, the pitching became a key role to decide a team who entered or eliminated the semi-final.

Wednesday, February 23, 2005A compound in the common daisy-like plant feverfew kills human leukemia stem cells and could form the basis for newer, more effective drugs for the disease.

American researchers at the University of Rochester Medical Center in New York say that it could take months to develop a useable drug from the compound, parthenolide.

However, they are working to do so with chemists at the University of Kentucky who have identified a water-soluble molecule with the same properties. The US National Cancer Institute has also accepted the work into its rapid access program, which aims to speed experimental drugs into human clinical trials.

“This research is a very important step in setting the stage for future development of a new therapy for leukemia,” says Rochester researcher Craig Jordan. “We have proof that we can kill leukemia stem cells with this type of agent, and that is good news.”

Parthenolide appears to target the roots of myeloid leukemia, stem cells, while current treatments including the relatively new drug Gleevec don’t. So, “You’re pulling the weed without getting to the root,” says Jordan.

Used for centuries to fight fevers, inflammation and arthritis, feverfew earned interest from the Rochester researchers after other scientists showed that it could prevent skin cancer in animal models.

So the researchers investigated how a concentrated form of the plant component parthenolide would affect leukemia cells and normal cells.

Comparing the impact of parthenolide to the common chemotherapy drug cytarabine, they found that parthenolide selectively killed leukemia cells while sparing normal cells better.

While the findings suggest that parthenolide is a good starting point for new drugs, people with leukemia aren’t being encouraged to take high doses of feverfew as they could not take enough of the remedy to halt the disease.

The research is reported in the journal Blood.

Monday, August 21, 2006

A report by the International Water Management Institute (IWMI) says rising demand for irrigation to produce food and biofuels will aggravate scarcities of water. “One in three people is enduring one form or another of water scarcity,” states the report compiled by 700 experts.

IWMI warns there has to be a radical transformation in the management of water resources – citing as examples Australia, south-central China, and last year’s devastating drought in India. Report authors claim that the price of water could double or triple over the next two decades. The report, backed by the United Nations and farm research groups, shows that globally, water usage had increased by six times in the past 100 years and would double again by 2050 – driven mainly by irrigation and demands by agriculture.

Record oil prices and concerns about rapid onset climate change are driving more countries to produce biofuels – from sugarcane, corn or wood – as an alternative to fossil fuel. “If people are growing biofuels and food it will put another new stress,” says David Molden, who led the study at the Sri Lanka-based IWMI. “The big solution is to find ways to grow more food with less water. Basically, more crop per drop,” Molden said. “The number one recommendation… is to look to improve rain-fed systems in Sub-Saharan Africa and South Asia.”

The report says conquering hunger and coping with an estimated 3 billion more humans by 2050 will result in an 80 percent increase in water use for agriculture. Irrigation absorbs around 74 percent and is likely to surge by 2050.

“We will have to change business as usual in order to deal with growing scarcity,” said Frank Rijsberman, director general of the IWMI, of the report released at the 2006 “World Water Week” conference in Stockholm. Solutions included helping poor countries to grow more food with available fresh water via simple, low-cost measures, a shift from past policies that favoured expensive dams or canals, the report said.

According to Rijsberman, there are two types of shortages: those observed in regions where water is over-exploited, causing a lowering of groundwater levels and rivers to dry up; and those in countries lacking the technical and financial resources to capture water – despite its abundance.

Billions of people in Asia and Africa already faced water shortages because of poor water management, he said. “We will not run out of bottled water any time soon, but some countries have already run out of water to produce their own food,” he said.

The report said that a calorie of food took roughly 1 litre of water to produce, with a kilo of grain needing only 500-4,000 litres compared to a kilo of industrially produced meat taking 10,000 litres.

“Without improvements in water productivity the consequences of this will be even more widespread water scarcity and rapidly increasing water prices.” Rijsberman said water scarcity in Africa was caused by a lack of infrastructure to get the water to the people who needed it. “The water is there, the rainfall is there, but the infrastructure isn’t there,” Rijsberman told reporters.

Other recommendations for certain regions include the extension and the improvement of agriculture using rainwater, the introduction of cereal varieties that need less water as well as the development of irrigation systems.

But the priority, Rijsberman stresses, is to change mentalities and often outdated government policies. “Government policies and their approach to water are probably the most urgent that need changing in the short term,” he said.

There is, he says, enough land, water and human capacity to produce enough food for a growing population over the next 50 years, but one of the challenges is to provide enough water for agriculture without damaging the environment. “Agriculture is driving water scarcity and water scarcity is driving environmental degradation and destruction,” he said.

In Australia last week, Rijsberman said he would “not be surprised to see the price of water double or triple over the next two decades.”

Thursday, May 31, 2007

According to The Japan Times, the 20-year-old Japanese delegate Riyo Mori was crowned as the 56th Miss Universe, in a ceremony held at Mexico City on May 28 .

Riyo, the new Miss Universe titleholder, is from Shizuoka, Japan. She had stayed in Canada to study ballet while in high-school.After Riyo returned to her country, she became to an instructor of a dance school.

Riyo Mori achieved the brilliant feat of winning this beauty contest as Japanese after 48 years’ absence.Incidentally, preceded runner-up is Kurara Chibana.

Friday, May 19, 2006

This interview intends to provide some insight into OpenSync, an upcoming free unified data synchronization solution for free software desktops such as KDE, commonly used as part of the GNU/Linux operating system.

Hi Cornelius, Armin and Tobias. As you are now getting close to version 1.0 of OpenSync, which is expected to become the new synchronisation framework for KDE and other free desktops, we are quite interested in the merits it can provide for KDE users and for developers, as well as for the Open Source Community as a whole. So there’s one key-question before I move deeper into the details of OpenSync:

What does OpenSync accomplish, that no one did before?

Cornelius:

First of all it does its job of synchronizing data like addressbooks and calendars between desktop applications and mobile devices like PDAs and cell phones.

But the new thing about OpenSync is that it isn’t tied to a particular device or a specific platform. It provides an extensible and modular framework that is easy to adopt for application developers and people implementing support for syncing with mobile devices.

OpenSync is also independent of the desktop platform. It will be the common syncing backend for at least KDE and GNOME and other projects are likely to join. That means that the free desktop will have one common syncing solution. This is something really new.

How do the end-users profit from using synching solutions that interface with OpenSync as framework?

Cornelius:

First, the users will be able to actually synchronize all their data. By using one common framework there won’t be any “missing links”, where one application can sync one set of devices and another application a different one. With OpenSync all applications can sync all devices.

Second, the users will get a consistent and common user interface for syncing across all applications and devices. This will be much simpler to use than the current incoherent collection of syncing programs you need if you have more than the very basic needs.

How does OpenSync help developers with coding?

Cornelius:

It’s a very flexible and well-designed framework that makes it quite easy for developers to add support for new devices and new types of data. It’s also very easy to add support for OpenSync to applications.

The big achievement of OpenSync is that it hides all the gory details of syncing from the developers who work on applications and device support. That makes it possible for the developers to concentrate on their area of expertise without having to care what’s going on behind the scenes.

I have written quite a lot of synchronization code in the past. Trust me, it’s much better, if someone just takes care of it for you, and that’s what OpenSync does.

Tobias:

Another point to mention is the python wrapper for opensync, so you are not bound to C or C++, but can develop plugins in a high level scripting language.

Why should producers of portable devices get involved with your team?

Cornelius:

OpenSync will be the one common syncing solution for the free desktop. That means there is a single point of contact for device manufacturers who want to add support for their devices. That’s much more feasible than addressing all the different applications and solutions we had before. With OpenSync it hopefully will become interesting for manufacturers to officially support Linux for their devices.

Do you also plan to support applications of OpenSync in proprietary systems like OSX and Windows?

Cornelius:

OpenSync is designed to be cross-platform, so it is able to run on other systems like Windows. How well this works is always a question of people actually using and developing for this system. As far as I know there isn’t a real Windows community around OpenSync yet. But the technical foundation is there, so if there is somebody interested in working on a unified syncing solution on Windows, everybody is welcome to join the project.

What does your synchronisation framework do for KDE and for KitchenSync in particular?

Cornelius:

OpenSync replaces the KDE-specific synchronization frameworks we had before. Even in KDE we had several separate syncing implementations and with OpenSync we can get replace them with a common framework. We had a more generic syncing solution in KDE under development. This was quite similar from a design point of view to OpenSync, but it never got to the level of maturity we would have needed, because of lack of resources. As OpenSync fills this gap we are happy to be able to remove our old code and now concentrate on our core business.

What was your personal reason for getting involved with OpenSync?

Cornelius:

I wrote a lot of synchronization code in the past, which mainly came from the time where I was maintaining KOrganizer and working on KAddressBook. But this always was driven by necessity and not passion. I wanted to have all my calendar and contact data in one place, but my main objective was to work on the applications and user interfaces handling the data and not on the underlying code synchronizing the data.

So when the OpenSync project was created I was very interested. At GUADEC in Stuttgart I met with Armin, the maintainer of OpenSync, and we talked about integrating OpenSync with KDE. Everything seemed to fit together quite well, so at Linuxtag the same year we had another meeting with some more KDE people. In the end we agreed to go with OpenSync and a couple of weeks later we met again in Nuernberg for three days of hacking and created the KDE frontend for OpenSync. In retrospect it was a very pleasant and straightforward process to get where we are now.

Armin:

My reason to get involved (or better to start) OpenSync was my involvement with its predecessor Multisync. I am working as a system administrator for a small consulting company and so I saw some problems when trying to find a synchronization solution for Linux.

At that point I joined the Multisync project to implement some plugins that I thought would be nice to have. After some time I became the maintainer of the project. But I was unhappy with some technical aspects of the project, especially the tight coupling between the syncing logic and the GUI, its dependencies on GNOME libraries and its lack of flexibility.

Tobias:

Well, I have been a KDE PIM developer for several years now, so there was no way around getting in touch with synchronization and KitchenSync. Although I liked the idea of KitchenSync, I hated the code and the user interface […]. So when we discussed to switch to OpenSync and reimplementing the user interface, I volunteered immediately.

Can you tell us a bit about your further plans and ideas?

Cornelius:

The next thing will be the 1.0 release of OpenSync. We will release KitchenSync as frontend in parallel.

Armin:

There are of course a lot of things on my todo and my wishlist for opensync. For the near future the most important step is the 1.0 release, of course, where we still have some missing features in OpenSync as well as in the plugins.

One thing I would really like to see is a thunderbird plugin for OpenSync. I use thunderbird personally and would really like to keep my contacts up to date with my cellular, but I was not yet able to find the time to implement it.

Tobias:

One thing that would really rock in future versions of OpenSync is an automatic hardware detection mechanism, so when you plugin your Palm or switch on your bluetooth device, OpenSync will create a synchronization group automatically and ask the user to start syncing. To bring OpenSync to the level of _The Syncing Solution [tm]_ we must reduce the necessary configuration to a minimum.

What was the most dire problem you had to face when creating OpenSync and how did you face it?

Cornelius:

Fortunately the problems which I personally would consider to be dire are solved by the implementation of OpenSync which is well hidden from the outside world and [they are] an area I didn’t work on 😉

Armin:

I guess that I am the right person to answer this question then 🙂

The most complicated part of OpenSync is definitely the format conversion, which is responsible for converting the format of one device to the format that another device understands.

There are a lot of subsystems in this format conversion that make it so complex, like conversion path searching, comparing items, detection of mime types and last but not least the conversion itself. So this was a hard piece of work.

What was the greatest moment for you?

Cornelius:

I think the greatest moment was when, after three days of concentrated hacking, we had a first working version of the KDE frontend for OpenSync. This was at meeting at the SUSE offices in Nuernberg and we were able to successfully do a small presentation and demo to a group of interested SUSE people.

Armin:

I don’t remember a distinct “greatest moment”. But what is a really great feeling is to see that a project catches on, that other people get involved, use the code you have written and improve it in ways that you haven’t thought of initially.

Tobias:

Hmm, also hacking on OpenSync/KitcheSync is much fun in general, the greatest moment was when the new KitchenSync frontend synced two directories via OpenSync the first time. But it was also cool when we managed to get the IrMC plugin working again after porting it to OpenSync.

As we now know the worst problem you faced and your greatest moment, the only one missing is: What was your weirdest experience while working on OpenSync?

Cornelius:

Not directly related to OpenSync, but pretty weird was meeting a co-worker at the Amsterdam airport when returning from the last OpenSync meeting. I don’t know how high the chance is to meet somebody you know on a big random airport not related at all to the places where you or the other person live, but it was quite surprising.

Tobias:

Since my favorite language is C++, I was always confused how people can use plain C for such a project, half the time your are busy with writing code for allocating/freeing memory areas. Nevertheless Armin did a great job and he is always a help for solving strange C problems 🙂

Now I’d like to move on to some more specific questions about current and planned abilities of OpenSync. As first, I’ve got a personal one:

I have an old iPod sitting around here. Can I or will I be able to use a program utilizing OpenSync to synchronize my calendars, contacts and music to it?

Cornelius:

I’m not aware of any iPod support for OpenSync up to now, but if it doesn’t exist yet, why not write it? OpenSync makes this easy. This is a chance for everybody with the personal desire to sync one device or another to get involved.

Armin:

I dont think that there is iPod support yet for OpenSync. But it would definitely be possible to use OpenSync for this task. So if someone would like to implement an iPod plugin, I would be glad to help 🙂

Which other devices do you already support?

Cornelius:

At this time, OpenSync supports Palms, SyncML and IrMC capable devices.

Which programs already implement OpenSync and where can we check back to find new additions?

Cornelius:

On the application side there is support for Evolution [GNOME] and Kontact with KitchenSync [KDE] on the frontend side and the backend side and some more. I expect that further applications will adopt OpenSync once the 1.0 version is released.

Armin:

Besides kitchensync there already are a command line tool and a port of the multisync GUI. Aside from the GUIs, I would really like to see OpenSync being used in other applications as well. One possibility for example would to be integrate OpenSync into Evolution to give users the possibility to synchronize their devices directly from this application. News can generally be found on the OpenSync web site www.opensync.org.

It is time to give the developers something to devour, too. I’ll keep this as a short twice-fold technical dive before coming to the takeoff question, even though I’m sure there’s information for a double-volume book on technical subleties.

As first dive: How did you integrate OpenSync in KitchenSync, viewed from the coding side?

Cornelius:

OpenSync provides a C interface. We wrapped this with a small C++ library and put KitchenSync on top. Due to the object oriented nature of the OpenSync interfaces this was quite easy.

Recently I also started to write a D-Bus frontend for OpenSync. This also is a nice way to integrate OpenSync which provides a wide variety of options regarding programming languages and system configurations.

And for the second, deeper dive:

Can you give us a quick outline of those inner workings of OpenSync, from the developers view, which make OpenSync especially viable for application in several different desktop environments?

Cornelius:

That’s really a question for Armin. For those who are interested I would recommend to have a look at the OpenSync website. There is a nice white paper about the internal structure and functionality of OpenSync.

Armin:

OpenSync consists of several parts:

First there is the plugin API which defines what functions a plugin has to implement so that OpenSync can dlopen() it. There are 2 types of plugins:

A sync plugin which can synchronize a certain device or application and which provides functions for the initialization, handling the connection to a device and reading and writing items. Then there is a format plugin which defines a format and how to convert, compare and detect it.

The next part is a set of helper functions which are provided to ease to programming of synchronization plugins. These helper functions include things like handling plugin config files, HashTables which can be used to detect changes in sets of items, functions to detect when a resync of devices is necessary etc.

The syncing logic itself resides in the sync engine, which is a separate part. The sync engine is responsible for deciding when to call the connect function of a plugin, when to read or write from it. The engine also takes care of invoking the format conversion functions so that each plugin gets the items in its required format.

If you want more information and details about the inner workings of OpenSync, you should really visit the opensync.org website or ask its developers.

To add some more spice for those of our readers, whose interest you just managed to spawn (or to skyrocket), please tell us where they can get more information on the OpenSync Framework, how they can best meet and help you and how they can help improving sync-support for KDE by helping OpenSync.

Cornelius:

Again, the OpenSync web site is the right source for information. Regarding the KDE side, the kde-pim@kde.org mailing list is probably the right address. At the moment the most important help would be everything which gets the OpenSync 1.0 release done.

[And even though] I already said it, it can’t be repeated too often: OpenSync will be the one unified syncing solution for the free desktop. Cross-device, cross-platform, cross-desktop.

It’s the first time I feel well when thinking about syncing 😉.

Armin:

Regarding OpenSync, the best places to ask would be the opensync mailing lists at sourceforge or the #opensync irc channel on the freenode.net servers.

There are always a lot of things where we could need a helping hand and where we would be really glad to get some help. So everyone who is interested in OpenSync is welcome to join.

Many thanks for your time!

Cornelius:

Thanks for doing the interview. It’s always fun to talk about OpenSync, because it’s really the right thing.

Armin:

Thank you for taking your time and doing this interview. I really appreciate your help!

Tobias:

Thanks for your work. Publication and marketing is something that is really missing in the open source community. We have nice software but nobody knows 😉

Further Information on OpenSync can be found on the OpenSync Website: www.opensync.org

This Interview was done by Arne Babenhauserheide in April 2006 via e-mail and KOffice on behalf of himself, the OpenSource Community, SpreadKDE.org and the Dot (dot.kde.org).It was first published on the Dot and is licensed under the cc-attribution-sharealike-license.A pdf-version with pictures can be found at opensync-interview.pdf (OpenDocument version: opensync-interview.odt)

Saturday, April 28, 2007

The Canadian Food Inspection Agency (CFIA) has issued border alerts for specific protein ingredients, imported from China, that may be incorporated into products destined for human consumption.

Inspectors from the Canada Border Services Agency (CBSA) will hold products, such as wheat and corn gluten, as well as soy and rice proteins until they can be tested for melamine, the contaminant found to have sickened pets through its use in pet food. If determined to be free of melamine, the ingredients will be released to the intended recipient. Materials such as glutens and protein powders are used commonly in many forms of food products.

The CFIA said it was not acting on specific information, but rather taking a cautious approach to human protection. “That’s why we have the border lookout for the ingredient, so that we can proactively assess any potential that the product is contaminated,” Paul Mayers of the CFIA told CBC News.

Since the border alert for melamine is a new procedure, the government can’t be sure if the contaminant made it into the food chain previously. The CFIA acknowledged that the same Chinese company under suspicion in the tainted pet food affair had shipped wheat gluten to a Canadian company, which in turn used it in food for fish farms. Although the fish were subsequently eaten by people, the CFIA believes the health risk from such consumption would be low.

In related news, Canadian researchers at the University of Guelph believe they may have determined the mechanism of how melamine caused illness in cats and dogs.

Both cyanuric acid and melamine were found in urine samples from pets that died after consuming contaminated pet food. The two compounds react with one another to form crystals that may block kidney function, researchers at the university said. The researchers observed crystals formed in cat urine by the addition of melamine and cyanuric acid. The composition of these crystals matches those found in the urine of affected pets when compared by infrared spectroscopy (FTIR).

“You wouldn’t normally expect to find those compounds in pet food, and hence nobody was really looking for it,” said John Melichercik, director of analytical laboratory services. “It’s just another piece of the puzzle along the way in this particular pet-food issue.”

Tuesday, November 20, 2007

Last night HBO premiered I Am An Animal: The Story of Ingrid Newkirk and PETA. Since its inception, People for the Ethical Treatment of Animals (PETA) has made headlines and raised eyebrows. They are almost single-handedly responsible for the movement against animal testing and their efforts have raised the suffering animals experience in a broad spectrum of consumer goods production and food processing into a cause célèbre.

PETA first made headlines in the Silver Spring monkeys case, when Alex Pacheco, then a student at George Washington University, volunteered at a lab run by Edward Taub, who was testing neuroplasticity on live monkeys. Taub had cut sensory ganglia that supplied nerves to the monkeys’ fingers, hands, arms, legs; with some of the monkeys, he had severed the entire spinal column. He then tried to force the monkeys to use their limbs by exposing them to persistent electric shock, prolonged physical restraint of an intact arm or leg, and by withholding food. With footage obtained by Pacheco, Taub was convicted of six counts of animal cruelty—largely as a result of the monkeys’ reported living conditions—making them “the most famous lab animals in history,” according to psychiatrist Norman Doidge. Taub’s conviction was later overturned on appeal and the monkeys were eventually euthanized.

PETA was born.

In the subsequent decades they ran the Stop Huntingdon Animal Cruelty against Europe’s largest animal-testing facility (footage showed staff punching beagle puppies in the face, shouting at them, and simulating sex acts while taking blood samples); against Covance, the United State’s largest importer of primates for laboratory research (evidence was found that they were dissecting monkeys at its Vienna, Virginia laboratory while the animals were still alive); against General Motors for using live animals in crash tests; against L’Oreal for testing cosmetics on animals; against the use of fur for fashion and fur farms; against Smithfield Foods for torturing Butterball turkeys; and against fast food chains, most recently against KFC through the launch of their website kentuckyfriedcruelty.com.

They have launched campaigns and engaged in stunts that are designed for media attention. In 1996, PETA activists famously threw a dead raccoon onto the table of Anna Wintour, the fur supporting editor-in-chief of Vogue, while she was dining at the Four Seasons in New York, and left bloody paw prints and the words “Fur Hag” on the steps of her home. They ran a campaign entitled Holocaust on your Plate that consisted of eight 60-square-foot panels, each juxtaposing images of the Holocaust with images of factory farming. Photographs of concentration camp inmates in wooden bunks were shown next to photographs of caged chickens, and piled bodies of Holocaust victims next to a pile of pig carcasses. In 2003 in Jerusalem, after a donkey was loaded with explosives and blown up in a terrorist attack, Newkirk sent a letter to then-PLO leader Yasser Arafat to keep animals out of the conflict. As the film shows, they also took over Jean-Paul Gaultier‘s Paris boutique and smeared blood on the windows to protest his use of fur in his clothing.

The group’s tactics have been criticized. Co-founder Pacheco, who is no longer with PETA, called them “stupid human tricks.” Some feminists criticize their campaigns featuring the Lettuce Ladies and “I’d Rather Go Naked Than Wear Fur” ads as objectifying women. Of their Holocaust on a Plate campaign, Anti-Defamation League Chairman Abraham Foxman said “The effort by PETA to compare the deliberate systematic murder of millions of Jews to the issue of animal rights is abhorrent.” (Newkirk later issued an apology for any hurt it caused). Perhaps most controversial amongst politicians, the public and even other animal rights organizations is PETA’s refusal to condemn the actions of the Animal Liberation Front, which in January 2005 was named as a terrorist threat by the United States Department of Homeland Security.

David Shankbone attended the pre-release screening of I Am An Animal at HBO’s offices in New York City on November 12, and the following day he sat down with Ingrid Newkirk to discuss her perspectives on PETA, animal rights, her responses to criticism lodged against her and to discuss her on-going life’s work to raise human awareness of animal suffering. Below is her interview.